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    祝贺华中农业大学老师使用南京卡米洛ELISA试剂盒发表分文章获高分录取!

    发布时间: 2023-05-19  点击次数: 542次

    文献标题

    GPA peptide enhances Nur77 expression in intestinal epithelial cells to exert a protective effect against DSS-induced colitis

    文献作者

    Zhao Deng1、Liufeng Zheng、Xiaowei Xie1、Hongkui Wei、Jian Peng

    期刊名称

    FASEB Journal

    影响因子

    5.191

    使用产品

    小鼠髓过氧化物酶(Myeloperoxidase ,MPO)ELISA试剂盒

    货号

    2M-KMLJM220987m

    小鼠活性氧(reactive oxygen species, ROS)ELISA试剂盒

    2M-KMLJM219615m

    人活性氧(reactive oxygen species, ROS)ELISA试剂盒

    2H-KMLJh310725


    Abstract

    Ulcerative colitis (UC) is a widespread inflammatory bowel disease that causes longlasting inflammation and ulcers in the colon and rectum. In the inflamed tissue of  patients with UC, the tight junctions are disrupted and large amounts of pro-inflammatory cytokines are produced, resulting in immune dysregulation. The expression  of Nur77 is significantly reduced in the colon of inflammatory bowel disease, while  Nur77 deficiency increases the susceptibility to DSS-induced colitis. Here, we report  that Gly-Pro-Ala (GPA) peptide isolated from fish skin gelatin hydrolysate can significantly alleviate intestinal inflammation and damage caused by DSS-induced mice  colitis. Besides maintaining the intestinal epithelial barrier, GPA alleviates intestinal inflammation and oxidative stress by inhibiting NF-κB activation. Interestingly,  GPA binds to the ligand-binding domain of Nur77 and stimulates its autotranscriptional activity to enhance its expression in intestinal epithelial cells. Furthermore,  GPA activates the promoter of IκBα to increase its expression, resulting in the abolishment of the NF-κB pathway. In contrast, the inhibitory effects of GPA on colitis  are abolished in Nur77-/- mice. Our results suggest that as a Nur77 modulator, GPA  may be applied to the prevention of intestinal inflammation


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